New Job Downstream Processing Scientist - Biologics In Quebec

Downstream Processing Scientist - Biologics
Downstream Processing Scientist - Biologics

Downstream Processing Scientist - Biologics

Company : National Research Council Canada
Salary : $57,220–$161,754 a year
Location : Quebec

Full Description

Help bring research to life and drive your career forward with the National Research Council of Canada (NRC), Canada’s largest research and technology organization.

We are looking for a Downstream Processing Scientist – Biologics to support our Human Health Therapeutics (HHT) Research Centre. This person would be someone who shares our core values of Integrity, Excellence, Respect and Creativity.

The candidate will provides leadership and a wide range of expertise in downstream process (DSP) development of biologics drugs including proteins, VLPs, viral vectors, plasmids and mRNA. Develops a robust and scalable process following principles of Quality by Design (QbD) and in compliance with required regulatory guidelines. Supports process scale-up, gap analysis and tech-transfer to a GMP facility. Assist in GMP batch production and prepare required documentation. Lead DSP R&D projects that accelerate portfolio programs and projects.

In this regard, the position:

  • Develops, adapts and implements novel purification processes and related analytics for biologics, vaccine and cell and gene-therapy programs;
  • Finding novel solutions to complex purification or assays problems based on current cutting edge approaches;
  • Performs feasibility assessment, gap analysis, process scale-up and tech-transfer to a GMP facility.
  • Generates required documents for tech-transfer, assist in GMP batch production.
  • Plans, develops and leads internal and/or client focused projects in support of Portfolio goals;
  • Participate in and demonstrates leadership in project planning, including the prioritization and identification of the requirements for projects;
  • Maintains relevant intelligence and information on projects to assist in developing new project proposals;
  • Provides guidance, direction and development to portfolio managers, project and team leaders in the area of biologics downstream processing and analytics needed in biomanufacturing;
  • Undertakes special projects or assignments to further support the research center’s objectives in support of programs and projects, and project management.

Screening Criteria

Applicants must demonstrate within the content of their application that they meet the following screening criteria in order to be given further consideration as candidates:


Ph.D degree in Bioprocessing, Biotechnology, Biochemistry or any other life science discipline and experience in protein and or virus’s purification development, production and analytics.

A combination of university degree relevant to the position with significant experience may be considered.

For information on certificates and diplomas issued abroad, please see Degree equivalency


  • Significant experience in robust and efficient downstream process development of therapeutics proteins and viruses from various production platforms.
  • Significant experience on various lab-scale chromatography and filtration equipment and skids at pilot scale.
  • Significant experience in process scale-up, troubleshooting and tech-transfer.
  • Significant experience developing and applying protein and virus characterization analytical assays supporting purification processes development.
  • Experience in writing project proposal, study plans, client reports, SOPs, tech-transfer documents.
  • Experience of cGMP working environment.
  • Experience with virus purification.

Condition of Employment

Reliability Status

Must be able to possess and retain the physical capabilities to perform the position which include but may not be limited to: crouching, bending, twisting, walking, climbing stairs & ladders, and the ability to handle heavy and bulky objects.

Language Requirements

Bilingual Imperative BBB/BBB

Information on language requirements and self-assessment tests

Assessment Criteria

Candidates will be assessed on the basis of the following criteria:

Technical Competencies

  • Solid knowledge in bioprocessing, principles of protein, virus particles and nucleic acid based drug/vaccine purification processes and their practical applications.
  • Extensive knowledge of biochemical sciences, including protein purification, protein chemistry, protein characterization, and process optimization.
  • Extensive knowledge of various modality of chromatography (Affinity, IMAC, SEC, IEX, Mixed-Mode) and filtrations (depth filtration, TFF, nanofiltration and sterile filtration).

Behavioural Competencies

  • Research - Communication (Level 3)
  • Research - Creative thinking (Level 2)
  • Research - Results orientation (Level 3)
  • Research - Self-knowing and self-development (Level 2)
  • Research - Teamwork (Level 2)

Competency Profile(s)

For this position, the NRC will evaluate candidates using the following competency profile: Research


Relocation assistance will be determined in accordance with the NRC's directives.


This position is classified as a Research Council Officer (RCO), a group that is unique to the NRC. Candidates are remunerated based on their expertise, outcomes and impacts of their previous work experience relative to the requirements of the level. The salary scale for this group is vast, from $57,220 to $161,754 per annum, which permits for employees of all levels from new graduates to world-renowned experts to be fairly compensated for their contributions.

In addition, the incumbent will receive the Bilingualism Bonus of $800 per year.

NRC employees enjoy a wide-range of competitive benefits including comprehensive health and dental plans, pension and insurance plans, vacation and other leave entitlements.


  • A pre-qualified list may be established for similar positions for a one-year period.
  • Preference will be given to Canadian Citizens and Permanent Residents of Canada. Please include citizenship information in your application.
  • The incumbent must adhere to safe workplace practices at all times.
  • We thank all those who apply, however, only those selected for further consideration will be contacted.

Please direct your questions, with the requisition number (20090) to:

E-mail: [email protected]
Telephone: 438-304-7562
Closing Date: 18 September 2023 - 11:59 p.m. Eastern Time